Interleukin-1: Ariadne's Thread in Autoinflammatory and Autoimmune Disorders.

Interleukin-1 as a Common Denominator from Autoinflammatory to Autoimmune Disorders: Premises, Perils, and Perspectives

A complex web of dynamic relationships between innate and adaptive immunity is now evident for many autoinflammatory and autoimmune disorders, the first deriving from abnormal activation of innate immune system without any conventional danger triggers and the latter from self-/non-self-discrimination loss of tolerance, and systemic inflammation. Due to clinical and pathophysiologic similarities...

A case of autoinflammatory skin and bone disease flared by a change in osteoporosis management

IL: interleukin NR: normal range PAPA: pyogenic sterile arthritis, pyoderma gangrenosum, and acne PTH: parathyroid hormone SAPHO: synovitis, acne, pustulosis, hyperostosis, and osteitis WBC: white blood cell INTRODUCTION Autoinflammatory syndromes are an incompletely understood spectrum of diseases that involve spontaneous inflammation caused by genetic variants of the innate immune system. Unl...

Ariadne’s thread, daedalus’ wings and the learners autonomy

Autoimmune-autoinflammatory rheumatoid arthritis overlaps: a rare but potentially important subgroup of diseases

At the population level, rheumatoid arthritis (RA) is generally viewed as autoimmune in nature with a small subgroup of cases having a palindromic form or systemic autoinflammatory disorder (SAID) phenotype. Herein, we describe resistant cases of classical autoantibody associated RA that had clinical, genetic and therapeutic responses indicative of coexistent autoinflammatory disease. Five pati...

The Central Role of Anti-IL-1 Blockade in the Treatment of Monogenic and Multi-Factorial Autoinflammatory Diseases

Inherited autoinflammatory diseases are secondary to mutations of proteins playing a pivotal role in the regulation of the innate immunity leading to seemingly unprovoked episodes of inflammation. The understanding of the molecular pathways involved in these disorders has shed new lights on the pattern of activation and maintenance of the inflammatory response and disclosed new molecular therap...